Tackling the Challenges with Poorly Soluble Drugs

Submit Manuscript | http://medcraveonline.com J Anal Pharm Res 2015, 1(1): 00001 in terms of dissolution but the non-traditional formulation approaches can lead to a significant increase in dissolution and solubility particularly required for drugs applied in medium to higher dosages [3]. Such dosages’ requirements go along with the necessity to evaluate other formulation technologies for enhancing solubilization [4]. For instance, polymer based solid amorphous dispersions and surfactant based liquid selfemulsifying systems are alternative approaches to address these solubilization challenges. With the availability of innovative excipients, performance and robustness of drug delivery systems can be enhanced and offer more possibilities than ever before. For instance, Kaletra® marks the earlier tradition of transfer from lipid based emulsifying soft gel capsules (in 2000) to polymer based solid amorphous dispersion tablets (in 2005) [5].